Mixtures of an insecticide, a fungicide and a herbicide induce high toxicities and systemic physiological disturbances in winter Apis mellifera honey bees.
Identifieur interne : 000096 ( Main/Exploration ); précédent : 000095; suivant : 000097Mixtures of an insecticide, a fungicide and a herbicide induce high toxicities and systemic physiological disturbances in winter Apis mellifera honey bees.
Auteurs : Hanine Almasri [France] ; Daiana Antonia Tavares [France] ; Maryline Pioz [France] ; Déborah Sené [France] ; Sylvie Tchamitchian [France] ; Marianne Cousin [France] ; Jean-Luc Brunet [France] ; Luc P. Belzunces [France]Source :
- Ecotoxicology and environmental safety [ 1090-2414 ] ; 2020.
Descripteurs français
- KwdFr :
- Abeilles (physiologie), Animaux (MeSH), Composés nitrés (toxicité), Dioxolanes (toxicité), Fongicides industriels (toxicité), Glycine (analogues et dérivés), Glycine (toxicité), Herbicides (toxicité), Insecticides (toxicité), Néonicotinoïdes (toxicité), Pesticides (toxicité), Pollinisation (effets des médicaments et des substances chimiques), Synergie des médicaments (MeSH), Triazoles (toxicité).
- MESH :
- analogues et dérivés : Glycine.
- effets des médicaments et des substances chimiques : Pollinisation.
- physiologie : Abeilles.
- toxicité : Composés nitrés, Dioxolanes, Fongicides industriels, Glycine, Herbicides, Insecticides, Néonicotinoïdes, Pesticides, Triazoles.
- Animaux, Synergie des médicaments.
English descriptors
- KwdEn :
- Animals (MeSH), Bees (physiology), Dioxolanes (toxicity), Drug Synergism (MeSH), Fungicides, Industrial (toxicity), Glycine (analogs & derivatives), Glycine (toxicity), Herbicides (toxicity), Insecticides (toxicity), Neonicotinoids (toxicity), Nitro Compounds (toxicity), Pesticides (toxicity), Pollination (drug effects), Triazoles (toxicity).
- MESH :
- chemical , analogs & derivatives : Glycine.
- chemical , toxicity : Dioxolanes, Fungicides, Industrial, Glycine, Herbicides, Insecticides, Neonicotinoids, Nitro Compounds, Pesticides, Triazoles.
- drug effects : Pollination.
- physiology : Bees.
- Animals, Drug Synergism.
Abstract
Multiple pesticides originating from plant protection treatments and the treatment of pests infecting honey bees are frequently detected in beehive matrices. Therefore, winter honey bees, which have a long life span, could be exposed to these pesticides for longer periods than summer honey bees. In this study, winter honey bees were exposed through food to the insecticide imidacloprid, the fungicide difenoconazole and the herbicide glyphosate, alone or in binary and ternary mixtures, at environmental concentrations (0 (controls), 0.1, 1 and 10 μg/L) for 20 days. The survival of the honey bees was significantly reduced after exposure to these 3 pesticides individually and in combination. Overall, the combinations had a higher impact than the pesticides alone with a maximum mortality of 52.9% after 20 days of exposure to the insecticide-fungicide binary mixture at 1 μg/L. The analyses of the surviving bees showed that these different pesticide combinations had a systemic global impact on the physiological state of the honey bees, as revealed by the modulation of head, midgut and abdomen glutathione-S-transferase, head acetylcholinesterase, abdomen glucose-6-phosphate dehydrogenase and midgut alkaline phosphatase, which are involved in the detoxification of xenobiotics, the nervous system, defenses against oxidative stress, metabolism and immunity, respectively. These results demonstrate the importance of studying the effects of chemical cocktails based on low realistic exposure levels and developing long-term tests to reveal possible lethal and adverse sublethal interactions in honey bees and other insect pollinators.
DOI: 10.1016/j.ecoenv.2020.111013
PubMed: 32888588
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Pioz, Maryline" sort="Pioz, Maryline" uniqKey="Pioz M" first="Maryline" last="Pioz">Maryline Pioz</name><affiliation wicri:level="3"><nlm:affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Sene, Deborah" sort="Sene, Deborah" uniqKey="Sene D" first="Déborah" last="Sené">Déborah Sené</name><affiliation wicri:level="3"><nlm:affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Tchamitchian, Sylvie" sort="Tchamitchian, Sylvie" uniqKey="Tchamitchian S" first="Sylvie" last="Tchamitchian">Sylvie Tchamitchian</name><affiliation wicri:level="3"><nlm:affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</nlm:affiliation><country 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last="Brunet">Jean-Luc Brunet</name><affiliation wicri:level="3"><nlm:affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Belzunces, Luc P" sort="Belzunces, Luc P" uniqKey="Belzunces L" first="Luc P" last="Belzunces">Luc P. Belzunces</name><affiliation wicri:level="3"><nlm:affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France. Electronic address: luc.belzunces@inrae.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author></analytic><series><title level="j">Ecotoxicology and environmental safety</title><idno type="eISSN">1090-2414</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Bees (physiology)</term><term>Dioxolanes (toxicity)</term><term>Drug Synergism (MeSH)</term><term>Fungicides, Industrial (toxicity)</term><term>Glycine (analogs & derivatives)</term><term>Glycine (toxicity)</term><term>Herbicides (toxicity)</term><term>Insecticides (toxicity)</term><term>Neonicotinoids (toxicity)</term><term>Nitro Compounds (toxicity)</term><term>Pesticides (toxicity)</term><term>Pollination (drug effects)</term><term>Triazoles (toxicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Abeilles (physiologie)</term><term>Animaux (MeSH)</term><term>Composés nitrés (toxicité)</term><term>Dioxolanes (toxicité)</term><term>Fongicides industriels (toxicité)</term><term>Glycine (analogues et dérivés)</term><term>Glycine (toxicité)</term><term>Herbicides (toxicité)</term><term>Insecticides (toxicité)</term><term>Néonicotinoïdes (toxicité)</term><term>Pesticides (toxicité)</term><term>Pollinisation (effets des médicaments et des substances chimiques)</term><term>Synergie des médicaments (MeSH)</term><term>Triazoles (toxicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Glycine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Dioxolanes</term><term>Fungicides, Industrial</term><term>Glycine</term><term>Herbicides</term><term>Insecticides</term><term>Neonicotinoids</term><term>Nitro Compounds</term><term>Pesticides</term><term>Triazoles</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Glycine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pollination</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Pollinisation</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Abeilles</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bees</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Composés nitrés</term><term>Dioxolanes</term><term>Fongicides industriels</term><term>Glycine</term><term>Herbicides</term><term>Insecticides</term><term>Néonicotinoïdes</term><term>Pesticides</term><term>Triazoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Synergism</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Synergie des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple pesticides originating from plant protection treatments and the treatment of pests infecting honey bees are frequently detected in beehive matrices. Therefore, winter honey bees, which have a long life span, could be exposed to these pesticides for longer periods than summer honey bees. In this study, winter honey bees were exposed through food to the insecticide imidacloprid, the fungicide difenoconazole and the herbicide glyphosate, alone or in binary and ternary mixtures, at environmental concentrations (0 (controls), 0.1, 1 and 10 μg/L) for 20 days. The survival of the honey bees was significantly reduced after exposure to these 3 pesticides individually and in combination. Overall, the combinations had a higher impact than the pesticides alone with a maximum mortality of 52.9% after 20 days of exposure to the insecticide-fungicide binary mixture at 1 μg/L. The analyses of the surviving bees showed that these different pesticide combinations had a systemic global impact on the physiological state of the honey bees, as revealed by the modulation of head, midgut and abdomen glutathione-S-transferase, head acetylcholinesterase, abdomen glucose-6-phosphate dehydrogenase and midgut alkaline phosphatase, which are involved in the detoxification of xenobiotics, the nervous system, defenses against oxidative stress, metabolism and immunity, respectively. These results demonstrate the importance of studying the effects of chemical cocktails based on low realistic exposure levels and developing long-term tests to reveal possible lethal and adverse sublethal interactions in honey bees and other insect pollinators.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32888588</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>14</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2414</ISSN><JournalIssue CitedMedium="Internet"><Volume>203</Volume><PubDate><Year>2020</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Ecotoxicology and environmental safety</Title><ISOAbbreviation>Ecotoxicol Environ Saf</ISOAbbreviation></Journal><ArticleTitle>Mixtures of an insecticide, a fungicide and a herbicide induce high toxicities and systemic physiological disturbances in winter Apis mellifera honey bees.</ArticleTitle><Pagination><MedlinePgn>111013</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0147-6513(20)30852-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ecoenv.2020.111013</ELocationID><Abstract><AbstractText>Multiple pesticides originating from plant protection treatments and the treatment of pests infecting honey bees are frequently detected in beehive matrices. Therefore, winter honey bees, which have a long life span, could be exposed to these pesticides for longer periods than summer honey bees. In this study, winter honey bees were exposed through food to the insecticide imidacloprid, the fungicide difenoconazole and the herbicide glyphosate, alone or in binary and ternary mixtures, at environmental concentrations (0 (controls), 0.1, 1 and 10 μg/L) for 20 days. The survival of the honey bees was significantly reduced after exposure to these 3 pesticides individually and in combination. Overall, the combinations had a higher impact than the pesticides alone with a maximum mortality of 52.9% after 20 days of exposure to the insecticide-fungicide binary mixture at 1 μg/L. The analyses of the surviving bees showed that these different pesticide combinations had a systemic global impact on the physiological state of the honey bees, as revealed by the modulation of head, midgut and abdomen glutathione-S-transferase, head acetylcholinesterase, abdomen glucose-6-phosphate dehydrogenase and midgut alkaline phosphatase, which are involved in the detoxification of xenobiotics, the nervous system, defenses against oxidative stress, metabolism and immunity, respectively. These results demonstrate the importance of studying the effects of chemical cocktails based on low realistic exposure levels and developing long-term tests to reveal possible lethal and adverse sublethal interactions in honey bees and other insect pollinators.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Almasri</LastName><ForeName>Hanine</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavares</LastName><ForeName>Daiana Antonia</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pioz</LastName><ForeName>Maryline</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sené</LastName><ForeName>Déborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tchamitchian</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cousin</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brunet</LastName><ForeName>Jean-Luc</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belzunces</LastName><ForeName>Luc P</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>INRAE, UR 406 A&E, Laboratoire de Toxicologie Environnementale, 84914, Avignon, France. Electronic address: luc.belzunces@inrae.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Ecotoxicol Environ Saf</MedlineTA><NlmUniqueID>7805381</NlmUniqueID><ISSNLinking>0147-6513</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004148">Dioxolanes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005659">Fungicides, Industrial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006540">Herbicides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007306">Insecticides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000073943">Neonicotinoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009574">Nitro Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010575">Pesticides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014230">Triazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>3BN7M937V8</RegistryNumber><NameOfSubstance UI="C082359">imidacloprid</NameOfSubstance></Chemical><Chemical><RegistryNumber>4632WW1X5A</RegistryNumber><NameOfSubstance UI="C010974">glyphosate</NameOfSubstance></Chemical><Chemical><RegistryNumber>D9612XCH4P</RegistryNumber><NameOfSubstance UI="C115058">difenoconazole</NameOfSubstance></Chemical><Chemical><RegistryNumber>TE7660XO1C</RegistryNumber><NameOfSubstance UI="D005998">Glycine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001516" MajorTopicYN="N">Bees</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004148" MajorTopicYN="N">Dioxolanes</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004357" MajorTopicYN="N">Drug Synergism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005659" MajorTopicYN="N">Fungicides, Industrial</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005998" MajorTopicYN="N">Glycine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & 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UI="D054817" MajorTopicYN="N">Pollination</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014230" MajorTopicYN="N">Triazoles</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cocktail effects</Keyword><Keyword MajorTopicYN="N">Pesticide mixtures</Keyword><Keyword MajorTopicYN="N">Physiological state</Keyword><Keyword MajorTopicYN="N">Synergy</Keyword><Keyword MajorTopicYN="N">Winter honey bee</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>5</Day><Hour>12</Hour><Minute>16</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32888588</ArticleId><ArticleId IdType="pii">S0147-6513(20)30852-6</ArticleId><ArticleId IdType="doi">10.1016/j.ecoenv.2020.111013</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Avignon</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Almasri, Hanine" sort="Almasri, Hanine" uniqKey="Almasri H" first="Hanine" last="Almasri">Hanine Almasri</name></region><name sortKey="Belzunces, Luc P" sort="Belzunces, Luc P" uniqKey="Belzunces L" first="Luc P" last="Belzunces">Luc P. Belzunces</name><name sortKey="Brunet, Jean Luc" sort="Brunet, Jean Luc" uniqKey="Brunet J" first="Jean-Luc" last="Brunet">Jean-Luc Brunet</name><name sortKey="Cousin, Marianne" sort="Cousin, Marianne" uniqKey="Cousin M" first="Marianne" last="Cousin">Marianne Cousin</name><name sortKey="Pioz, Maryline" sort="Pioz, Maryline" uniqKey="Pioz M" first="Maryline" last="Pioz">Maryline Pioz</name><name sortKey="Sene, Deborah" sort="Sene, Deborah" uniqKey="Sene D" first="Déborah" last="Sené">Déborah Sené</name><name sortKey="Tavares, Daiana Antonia" sort="Tavares, Daiana Antonia" uniqKey="Tavares D" first="Daiana Antonia" last="Tavares">Daiana Antonia Tavares</name><name sortKey="Tchamitchian, Sylvie" sort="Tchamitchian, Sylvie" uniqKey="Tchamitchian S" first="Sylvie" last="Tchamitchian">Sylvie Tchamitchian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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